Technical information pluracare lf grades poloxamer. Poloxamers are also known by the trade names synperonics, pluronic, and. Poloxamers are also known by the trade names synperonics, pluronic, and kolliphor. Differential effects of commercialgrade and purified. You can find detailed information on our product range by looking up your industry or using our product finder. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Initially, the in vitro antileishmanial activity ic 50 value of ampbm and bampbm empty micelles against stationary promastigotes and amastigoteslike forms of the parasites was. The poloxamer synperonic f108 stock solution was stored at 4c. Among the poloxamers, poloxamer 407 with registered trademarks of pluronic f127 by basf laboratories and synperonic pef127 by icp.
Poly ethylene glycol block poly propylene glycol block poly ethylene glycol you have selected the maximum number of product attributes 3 to compare. Apr 17, 2020 they are used in pharmaceutical formulations as surfactants, emulsifying agents, solubilizing agent, dispersing agents, and as in vivo absorbance enhancers. Besides clothing, spandex is being gradually applied in the medical and other industries. About fagron fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding. The common available grades are poloxamer 68, 88, 98, 108, 124, 188, 237, 338, and 407 3. Assessment of transdermal penetration enhancement by topical pharmaceutical excipients using skin pampa method m. The common available grades are poloxamer 68, 88, 98, 108, 124, 188, 237, 338, and 407. Variability in poloxamer 188 p188 raw material, which is routinely used in cell culture media to protect cells from hydrodynamic forces, plays an important role in the process performance. The ease of production, the stability at 4 c or at room temperature and the low cost of the formulation, when compared to the phospholipids used in the liposomal formulations, are attractive conditions. Basf, ludwigshafen, germany was prepared in a stock solution of 100 mgml by dissolving it in sterile water overnight and filtering it through a 0. Kolliphor p 407 is used primarily as thickening agent and gel former, as well as coemulsifier and consistency enhancer in creams and liquid emulsions. Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of. The approximate lengths of the two peg blocks is 101 repeat units while the approximate length of the propylene. Fagron wants to widen the therapeutic scope of the.
Makon l61 poloxamer 181 liquid 3 2,000 24 32 162 makon l62 poloxamer 182 liquid 7 2,500 32 41 268 makon l64 poloxamer 184 liquid 15 2,900 58 18 312 makon l101 poloxamer 331 liquid 1 3,800 15 36 392 makon p6575 na paste 17 3,800 82 27 2222 makon p104 poloxamer 334 paste 5,900 82 32 4482 makon p105 poloxamer 335 paste 15 6,500 631 36 6262. Apart from its use in manual sugar coating, kollidon va 64 or kollidon 30. Pdf poloxamers, poloxamines and polymeric micelles. Poloxamer is available in different grade based on the physical parameter like molecular weight, weight % of oxyethylene etc. Poloxamer 407 about fagron fagrons strategy is focused on the optimization and innovation of pharmaceutical compounding. Basf offer all functional materials required for a successful formulation using melt granulation. Poloxamer 407 was a gift sample from basf corporation, mumbai. Emm 070801e00 january 2008 page 4 of 10 pluracare lf grades poloxamer applications it is suggested that these pluracare copolymers be considered for their general functionality as surfactants, emulsifiers, solubilizers and stabilizers in almost all. However, little is known in any quantitative sense of its effect on protein adsorption and aggregation. The high performance and safety of basf products is backed by comprehensive documentation so you know you can rely on us our flexible kolliphor solutions can be used for hotmelt and spraydrying processes basf poloxamers offer better solubilizing properties compared to hpmc, pvp and cyclodextrins.
Basf enlightens the auto industry altair engineering. Loratadine, solid dispersions, poloxamer 188, poloxamer 407. Poloxamer 188, european pharmacopoeia ep reference standard. The synthetic lubricants also provide sustainability benefits, for example, by helping to improve energy efficiency which reduces fuel consumption and decreases co 2 emissions. In the present study, a poloxamer 407based amphotericin b ampbcontaining polymeric micelles system ampbm was employed in the treatment of leishmania amazonensisinfected balbc mice. Even though tremendous efforts have been spent to understand the mechanism of poloxamers protection, the root cause for lot. Download brochures this page features a selection of our latest brochures. Synthesis and characterization of poloxamer 188grafted. Mar 31, 2016 variability in poloxamer 188 p188 raw material, which is routinely used in cell culture media to protect cells from hydrodynamic forces, plays an important role in the process performance. The sales representative responsible for your area will be happy to answer any questions you may have about our products. Basf is the first company in the world to offer triphenylphosphine tpp in the form of pellets. Wasan 1, ramaswamy subramanian, mona kwong division of pharmaceutics and biopharmaceutics, faculty of pharmaceutical sciences, university of british columbia, vancouver, british columbia, canada. Narayan1 1technical service, basf corporation, roxbury, nj, 2pharmaceutical marketing, basf corporation, mount olive, nj introduction lutrol f grades are block copolymers referred to as poloxamers, consisting of polyoxyethylene. In view of the many factors that may affect processing and application.
Poloxamer 407mediated alterations in the activities of enzymes regulating lipid metabolism in rats. Learn about poloxamer from patients first hand experiences and trusted online health resources, including dosage, side effects and interactions. At first glance, one might tend to believe that from the point of view of the gibbs. Poloxamers are also known by the trade names synperonics. A supercritical fluid extraction process was used to prepare p188p. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Renewable content and high biodegradability make a range of basfs finished lubricants. Poloxamer 407 has approximate block lengths of a 101 and b 56. Pge2 and poloxamer synperonic f108 enhance transduction of. Basf corporation evaluation of lutrol f grades prill vs. A nonionic surfactant that has general functionality of surfactant, emulsifier, solubilizer and stabilizer.
Sep 18, 2014 register now and get a free online msds binder. The word poloxamer was coined by the inventor, irving schmolka, who received the patent for these materials in 1973. Quantitation of poloxamers in pharmaceutical formulations. It is a surfactant functioning both as cleansing and solubilizing agent. Poloxamer 188 basf pluronic f68 is widely used as a shear.
Poloxamer is a common biopolymer in intradermal drugdelivery. Easy preparation of poloxamer 407 based sterile injectable. Assessment of transdermal penetration enhancement by. Poloxamer 407 pluronic f127based polymeric micelles for. Basf corporation was supported on a polystyrene divinyl benzene solid matrix xad4. Basfs finished lubricants ensure firstclass results in terms of gear wear, seal life, fluid oxidation and oil life. There is a possibility that this would work better than injections. Poloxamers, available also under the trademark pluronics basf, are a class of watersoluble nonionic aba and bab triblock copolymers. Poloxamer 407 is a triblock copolymer consisting of a central hydrophobic block of polypropylene glycol flanked by two hydrophilic blocks of polyethylene glycol peg. Poloxamer hydrogels for biomedical applications mdpi. Effect of poloxamer on release of poorly water soluble drug.
Through science and innovation we provide our customers with products to meet the current and future needs of business and society. Poloxamer 407 is a hydrophilic non ionic surfactant of the more general class of copolymers known as poloxamers. They make this highlyefficient intermediate, used in many types of applications, significantly easier and safer to handle. Poloxamer 188 and 407 standards with concentrations of 1. Basf pharma ingredients and services offers our solutionsoriented skin delivery platform to formulators of otc and rx topical. For certain active substances such as nifedipine, naproxen and fenticonazole as well as for essential oils in pharmaceutical formulations kolliphor p 407 is also used as a polymeric solubilizer. Because the lengths of the polymer blocks can be customized, many different poloxamers exist that have slightly different properties. Physical and chemical properties as described by leaf 1967, many poloxamers dissolve in water and form gels when a concentrated aqueous solution is made. Polythf for spandex and elastane basf intermediates. Modulation of protein adsorption by poloxamer 188 in relation. Pluracare f127 finds application in toothpaste, whitening gels, mouthwash, sun and skin care applications. Poloxamer 407 is a hydrophilic nonionic surfactant of the more general class of copolymers known as poloxamers. The methods of determination are described in this monograph or in the general methods to be found in the european pharmacopoeia.
Assessment of transdermal penetration enhancement by topical. Supelco in a highpressure stainless steel vessel and extracted with carbon dioxide and modifying cosolvents approximately 4 mole % at 6,000 psi and 40 c. Thermogelling properties of purified poloxamer 407 ncbi. Lutrol f 68 meets the requirements of the current uspnf family monograph, poloxamer. Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene polypropylene oxide flanked by two hydrophilic chains of polyoxyethylene polyethylene oxide. Basf pharmaceuticalgrade ingredients for the dermatology industry. Wasan 1, ramaswamy subramanian, mona kwong division of pharmaceutics and biopharmaceutics, faculty of pharmaceutical sciences, university of british columbia, vancouver, british columbia, canada ira j. Poloxamer 188 chemical information, properties, structures, articles, patents and more chemical data. It appears that your browser has javascript disabled. Multiblock poloxamer surfactants suppress aggregation of denatured proteins article pdf available in biochimica et biophysica acta 17801. Narayan1 1technical service, basf corporation, roxbury, nj, 2pharmaceutical marketing, basf corporation, mount olive, nj.
Thermogelling properties of purified poloxamer 407. Mining solutions innovative chemistry meeting the challenges of mining industry customers basfs mining solutions business offers a diverse range of mineral processing and hydrometallurgical chemistries and technologies to improve process efficiencies and aid the economic extraction of valuable resources. They make this highlyefficient intermediate, used in many types of. Poloxamer 184 poloxamer 184 is a polyoxyethylene, polyoxypropylene block polymer. Basf to develop a high purity poloxamer for mast therapeutics. Mechanism investigation for poloxamer 188 raw material. English pdf, 627 kb superb foam with the pu fixed poker from basf.
Ch 3 hoch 2ch 2o xch 2cho ych 2ch 2o xh lutrol f 68 nf important. Dystrophic heart failure blocked by membrane sealant. Poloxamer 188 emprove expert cell culture optimized cas 9003. If you decide to use photos or graphics belonging to inge gmbh, please clearly indicate this fact in the list of references or the image caption. Among this family of copolymers, poloxamer 407 is a nonionic surfactant with reversible gelation properties above a particular polymer concentration and a particular temperature. Pluracare l 64 is a copolymer of ethylene oxide and propylene oxide with an average molecular weight of 2,900. Table 2 different poloxamine varieties commercialized by basf. Dystrophic heart failure blocked by membrane sealant poloxamer.
They are also used in topical dosage forms and rectal suppositories. Poloxamer 188 emprove expert cell culture optimized cas 9003116 stabilized with 70 ppm bht find msds or sds, a coa, data sheets and more information. Pdf multiblock poloxamer surfactants suppress aggregation. Poloxamer 105 benzoate is an ester of poloxamer 105 and benzoic acid and poloxamer 182 dibenzoate is the diester of poloxamer 182 and benzoic acid gottschalck and mcewen 2004. Poloxamers are triblock copolymers with a center block of hydrophobic polypropylene oxide ppo flanked by two hydrophilic polyethyleneoxide peo blocks. Modulation of protein adsorption by poloxamer 188 in.
As a highly elastic synthetic fiber, spandex, or elastane, is currently a very popular textile material. Rheology modifiers pdf, 859 kb rheology modifiers product recommendations for asia pacific pdf, 171 kb rheology modifiers product recommendations for europe pdf, 532 kb rheology modifiers product recommendations for north america pdf, 183 kb. Poloxamer 188 and poloxamer 407 stock standards were prepared by dissolving 200 mg of poloxamer in 100 ml of water to make 2. Lutrol f 127 it is recommended to use a preparation of the poloxamer with the active. In addition to poloxamer 188 nf, basf also offers comprehensive solutions to the pharmaceutical industry for both small and large molecule formulation needs. Poloxamer 407mediated alterations in the activities of. Poloxamer 407 pluronic f127 has been applied in a very broad range in biomedical and pharmaceutical industries torchilin et al. German pdf, 6 mb english pdf, 6 mb chemistry creates versatility.
868 221 1477 403 804 410 327 1089 347 1075 790 632 1172 652 147 1576 1426 1577 1218 272 1076 1226 1352 1497 1051 992 1472 1129 386 1445 847 1215 1181 389 1135 345 1527 1379 736 598 601 47 547 1490 8 5 635 211